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The PARADIGM-HF trial of LCZ696 — a novel compound that both blocks the renin-angiotensin system with an ARB component and blocks neprilysin’s degradation of natriuretic peptides — increased survival in heart failure by some 20% relative to enalapril. It seems to be a big deal, and the trial’s two principal authors have agreed to talk about their work and its larger meaning.

Running time: 15 minutes

Other links:

The study in the New England Journal of Medicine (free)

NEJM Journal Watch coverage of the study (free)

The post Podcast 174: PARADIGM and Heart Failure first appeared on Clinical Conversations.","publishTimestamp":1410309029,"duration":924,"mediaUrl":"https://mcdn.podbean.com/mf/web/jy0paa33wm0h4amw/clinical_conversations_podcasts_jwatch_org_media_JWPodcast174.mp3","mediaType":"audio/mpeg","shareLink":"https://admin5.podbean.com/embed.html?id=pb-t8rp6-19abf87","likedCount":0,"deepLink":"https://www.podbean.com/ew/pb-t8rp6-19abf87","transcriptUrl":null,"permalink":"/e/podcast-174-paradigm-and-heart%c2%a0failure-1761851693/","downloadLink":"https://www.podbean.com/media/share/pb-t8rp6-19abf87?download=1","fallbackResource":null,"fallbackResourceMimetype":null,"downloadCount":19,"status":"publish","hasMoreContent":false,"chaptersUrl":null,"explicit":false},"episodeShareLink":null,"deepLink":"https://www.podbean.com/ew/pb-t8rp6-19abf87","playlist":{"episodes":[],"current":0,"start":0,"stop":0,"playing":true,"playerLoading":true,"playbackRate":1,"playbackRateIndex":1,"volume":1},"toasts":[],"confirm":null,"customizeEditorFormZIndex":999,"lastRequestTime":null,"validateChangesOnBeforeunload":true,"windowWidth":1000,"VITE_FS1_CDN_URL_PREFIX":"https://pbcdn1.podbean.com/fs1","reloadStats":false,"userIdEncrypted":null,"userProfilePicture":null,"username":null,"isVerified":false,"loadUserInfo":false,"loginUrl":null,"recaptchaV3Loaded":false,"recaptchaV2Loaded":false,"likesLoaded":false,"commentLikeMap":{},"commentOffset":0,"widgetCommentsLoaded":false},"episode":{"id":"pb26918791","idTag":"t8rp6","title":"Podcast 174: PARADIGM and Heart Failure","logo":"https://pbcdn1.podbean.com/imglogo/image-logo/21574789/NEJM_JW_ClinConv-RGB-3000_300x300.jpg","shareLogo":"https://d2bwo9zemjwxh5.cloudfront.net/image-logo/21574789/NEJM_JW_ClinConv-RGB-3000_1200x628.jpg?s=a24f46324b663a31c1d1d6ffbc70647b&e=jpg","largeLogo":"https://pbcdn1.podbean.com/imglogo/image-logo/21574789/NEJM_JW_ClinConv-RGB-3000.jpg","previewContent":null,"content":"

Running time: 15 minutes